Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia

Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia.

Obstructive sleep apnea causes chronic intermittent hypoxia (IH) and is associated with impaired glucose metabolism, but mechanisms are unknown. Carotid bodies orchestrate physiological responses to hypoxemia by activating the sympathetic nervous system. Therefore, we hypothesized that carotid body denervation would abolish glucose intolerance and insulin resistance induced by chronic IH. Male ...

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Carotid body potentiation during chronic intermittent hypoxia: implication for hypertension

Autonomic dysfunction is involved in the development of hypertension in humans with obstructive sleep apnea, and animals exposed to chronic intermittent hypoxia (CIH). It has been proposed that a crucial step in the development of the hypertension is the potentiation of the carotid body (CB) chemosensory responses to hypoxia, but the temporal progression of the CB chemosensory, autonomic and hy...

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Appeasing the Carotid Body After Chronic Intermittent Hypoxia.

I recall vividly a conversation with the late Professor C. John Dickinson DM, FRCP, ARCO (Professor of Medicine and Chairman of the Department of Medicine at St. Bartholomew’s Hospital, London, 1975–1992) who remarked that in the majority of cases cardiovascular pathology occurred at night while asleep. John’s great hypothesis was that a shortage of oxygen to the brain because of high cerebrova...

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Appeasing the Carotid Body After Chronic Intermittent Hypoxia

I recall vividly a conversation with the late Professor C. John Dickinson DM, FRCP, ARCO (Professor of Medicine and Chairman of the Department of Medicine at St. Bartholomew’s Hospital, London, 1975–1992) who remarked that in the majority of cases cardiovascular pathology occurred at night while asleep. John’s great hypothesis was that a shortage of oxygen to the brain because of high cerebrova...

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Appeasing the Carotid Body After Chronic Intermittent Hypoxia

I recall vividly a conversation with the late Professor C. John Dickinson DM, FRCP, ARCO (Professor of Medicine and Chairman of the Department of Medicine at St. Bartholomew’s Hospital, London, 1975–1992) who remarked that in the majority of cases cardiovascular pathology occurred at night while asleep. John’s great hypothesis was that a shortage of oxygen to the brain because of high cerebrova...

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Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia

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